Chicken Alfredo Spaghetti Squash Casserole

Chicken Alfredo Spaghetti Squash Casserole is a creamy, comforting, and low-carb twist on a classic Italian favorite. Tender strands of roasted spaghetti squash are combined with juicy chicken and rich Alfredo sauce, then baked into a satisfying casserole that’s perfect for weeknight dinners or meal prep.

Why You’ll Love This Recipe

This dish gives you all the comfort of traditional pasta Alfredo without the heaviness. It’s packed with protein and veggies, naturally gluten-free, and full of creamy, cheesy flavor. Easy to prepare and bake ahead, it’s a cozy family favorite that fits a healthier lifestyle.

• Low-carb and gluten-free
• Rich, creamy, and satisfying
• Perfect for leftovers and meal prep
• Family-friendly and freezer-friendly
• Great way to use leftover chicken

ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

• Spaghetti squash
• Cooked chicken breast, shredded or chopped
• Butter
• Garlic, minced
• Heavy cream or half-and-half
• Cream cheese (optional for extra creaminess)
• Grated Parmesan cheese
• Mozzarella cheese
• Salt and black pepper
• Italian seasoning or parsley (optional)

directions

this recipe

1. Preheat oven to 400°F. Cut the spaghetti squash in half lengthwise, remove seeds, and place cut side down on a baking sheet. Roast for 35–40 minutes until tender. Let cool, then scrape out the strands with a fork.
2. While squash is roasting, prepare the Alfredo sauce. In a saucepan, melt butter over medium heat. Add garlic and cook until fragrant.
3. Stir in heavy cream and bring to a gentle simmer. Add cream cheese if using, and whisk until melted and smooth.
4. Stir in Parmesan cheese and season with salt, pepper, and Italian seasoning. Simmer until slightly thickened.
5. In a large bowl, combine the spaghetti squash strands, cooked chicken, and Alfredo sauce. Mix well.
6. Transfer the mixture to a greased casserole dish. Top with shredded mozzarella cheese.
7. Bake at 375°F for 20–25 minutes, or until hot and bubbly.
8. Broil for 2–3 minutes at the end to brown the cheese, if desired.
9. Garnish with fresh parsley and serve.

Servings and timing

This recipe makes 6 servings.
Prep time: 15 minutes
Cook time: 45 minutes (including squash roasting)
Total time: 1 hour

Variations

• Use rotisserie chicken: A great shortcut for quicker prep.
• Add veggies: Spinach, mushrooms, or broccoli mix in well.
• Make it dairy-free: Use dairy-free cream and cheese alternatives.
• Add spice: Stir in red pepper flakes or cayenne for a little heat.
• Make individual portions: Bake in ramekins for personal-sized servings.

storage/reheating

Store in an airtight container in the fridge for up to 4 days.
Reheat in the microwave or oven at 350°F until warmed through.
To freeze, assemble without baking, wrap tightly, and freeze for up to 2 months. Thaw in the fridge overnight and bake as directed.

FAQs

Can I cook the spaghetti squash in the microwave?

Yes, microwave halves face down in a dish with a little water for about 10–12 minutes.

Can I use jarred Alfredo sauce?

Yes, to save time, but homemade gives the best flavor and texture.

Is this dish keto-friendly?

Yes, it’s low in carbs and high in fat and protein, making it keto-compliant.

Can I make it ahead of time?

Yes, assemble the casserole and refrigerate up to a day in advance before baking.

What kind of chicken should I use?

Cooked and shredded or diced chicken breast, thigh meat, or even rotisserie chicken works well.

How do I prevent a watery casserole?

Let the spaghetti squash drain in a colander after roasting to release excess moisture.

Can I use other cheeses?

Yes, try Gruyère, Fontina, or provolone for a different flavor profile.

Is this freezer-friendly?

Yes, freeze before baking or freeze leftovers in individual portions.

How long does it need to rest before serving?

Let it sit for 5–10 minutes after baking so it sets slightly for easier serving.

Can I make this vegetarian?

Yes, skip the chicken and add more veggies or use a plant-based meat substitute.

Conclusion

Chicken Alfredo Spaghetti Squash Casserole is a creamy, crave-worthy dish that delivers comfort food satisfaction with a healthy twist. Whether you’re cutting carbs, avoiding gluten, or just love a lighter version of a classic favorite, this casserole is a weeknight win. Simple, versatile, and delicious—it’s a must-try for your dinner rotation.

Print